Structural and Functional View of Polypharmacology
نویسندگان
چکیده
منابع مشابه
A Structural and Functional View of Polypharmacology
The similarity property principle states that similar compounds have similar properties. In this study, we demonstrate that validity this principle holds well when the drug targets are protein domains. We leverage the similarity property principle to explore the druggability of CATH-FunFams, a type of protein domain and we use the associations between drugs and CATH-FunFams to explore drug poly...
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ژورنال
عنوان ژورنال: Scientific Reports
سال: 2017
ISSN: 2045-2322
DOI: 10.1038/s41598-017-10012-x